2025-2026

Gaze following in the operating room: enabling surgical role, phase, and team communication analysis

This project explores how analyzing where clinicians look in the operating room can help us understand complex surgical environments. By studying gaze following in the operating room, we aim to automatically identify team members' roles, recognize surgical phases, and detect team communications during the surgery.

  • Supervisors: V. Srivastav (ICube), D. Mutter (CHRU), N. Padoy (ICube & IHU Strasbourg)
  • Master's student: S. Baributsa

Planning for volumetric robot-assisted blood-brain- barrier opening

Disrupting the Blood-Brain Barrier (BBB) by using focused ultrasound (FUS) combined with
microbubbles injection is a promising way to treat brain diseases. However, for being effective, FUS
focus must be moved over a large area of the brain while taking into account microbubbles
concentration in the blood. This project will investigate the planning of 3D trajectories in order to
optimally cover brain regions defined pre-operatively, with a robotic arm holding the FUS transducer.

  • Supervisors: J. Vappou (ICube), F. Nageotte (ICube), P. Cabras (IGT & ICube)
  • Master's student: A. Carrara

SurgiLingo VQA: Developing & Benchmarking Causal Reasoning in Surgical Video for Multimodal AI

SurgiLingo is a new multimodal benchmark of short operative video clips that adds a rigorous Q&A layer to test whether multimodal AI models understand why surgeons act, not just what they do. It explores specifically left and right colectomy and total hysterectomy, pairing guideline-based questions with expert commentary. The student will craft high-quality Q&A pairs, an AI answering system and a benchmarking toolkit that checks factual accuracy, causal completeness, and citation of the correct surgical standard.

  • Supervisors: N. Padoy (ICube, IHU Strasbourg), P. Mascagni (IHU Strasbourg)
  • Master's student: Nicolas Chanel

Text modality as additional input for imitation learning to better teach a robot how to assist the nurses in the operation room

This work proposes to integrate textual instructions generated by an advanced language model into an imitation learning process for a medical assistant robot equipped with 6-degree-of-freedom manipulator arms and a 3D vision system. The goal is to enable the robot to better understand and perform specific tasks in the operating room by incorporating explicit textual cues provided through a speech recognition system.

  • Supervisors: M. Yguel (ICube), A. Garcia (IHU Strasbourg)
  • Master's student: David Genotelle

Behavior and brain activity under auditory beat stimulation in humans with attention deficits

 

Attention-deficit is a neuropathological symptom occurring in various neuropsychiatric disorders.
Pharmacological treatment may yield adverse cognitive side effects and non-pharmacological neuro-
stimulation is an alternative. The project investigates the longitudinal impact of auditory beat
stimulation on attention in healthy subjects with attention deficits. The student will perform psycho-
physical and neuro-physiological experiments in the presence of isochronic tones.

  • Supervisors: A. Hutt (ICube, INRIA), C. Gontier (ICube), A. Bonnefond (Inserm 1329)
  • Master's student: Rosario Huaranca

Differentiable simulation for parameter estimation and control of endovascular devices

Developing control algorithms for the automatic navigation of robotic endovascular devices is an
innovative approach for minimizing patient and physician exposure to X-rays. Realistic simulations
are essential to handle the complexity and uncertainty in the control of these devices. In this project,
we want to develop differentiable simulation tools as building blocks for improving the local control
of catheters as well as a way to estimate their physical properties from measurements gathered
during their navigation.

  • Supervisors: S. Cotin (INRIA, ICube), F. Nageotte (ICube)
  • Master's student: Abdallah Kenawi

Electroencephalography under magnetic neurmodulation of time prediction in schizophrenia

 

Schizophrenia is a psychiatric disorder that involves deficits in time prediction of actions. Magnetic
neuromodulation (rTMS) of the cerebellum in humans promises to alleviate subjects from pathological
symptoms. The present project aims to identify underlying brain processes of time prediction under
rTMS by estimating functional neural connectivity and brain activity sources from observed
electroencephalographic data and thus elucidate the origin of time prediction deficits.

  • Supervisors: A. Hutt (INRIA, ICube), A. Giersch (Inserm 1329)
  • Master's student: S. Lakhal

Robotization of a trans-oesophageal probe for interventional echocardiography

Interventional cardiology helps reduce invasiveness of a range of structural heart procedures. Guidance using transoesophageal echocardiography (TOE) is essential, but carries risks for the echocardiographers due to proximity with X-ray sources, and for the patient due to repeated gestures in long procedures. This project aims to design a robotic device for robotic control of the probe at a distance, combined with image-based guidance for enhanced procedures.

  • Supervisors: B. Rosa (ICube), E. Galli (CHRU, ICube), F. Nageotte (ICube)
  • Master's student: Léon Leroy

MYOMAT - Scanning electron microscopy image analysis of murine skeletal muscle extracellular matrix collagen fibers using morphological and deep learning approaches

The MYOMAT project aims to provide an original understanding of the organization and impact of the microscopic extracellular matrix of healthy, or pathological skeletal muscle, on its overall mechanical behavior. Through an innovative coupling of microscopy image analysis, biomechanics and genetics, it aims to identify the influence of the Klf10 gene on muscle properties via the refinement of a multiscale homogenized mechanical model of mouse skeletal muscle.

  • Supervisors: B. Naegel (ICube), S. Chatelin (ICube), S. Bensamoun (BMBI)
  • Master's student: Filippo Morini

Relationship between bone microstructure and mechanical behaviour of healthy and implanted femurs: micro-CT and modelling approach

Bone remodeling is essential for skeletal health and the success of orthopedic implants, particularly hip prostheses. By analyzing the microstructure of femoral bones and linking it with their intrinsic mechanical properties, this research aims at enhancing our understanding of bone-prosthesis interactions, with the goal of developing a numerical model that can predict and improve the integration and longevity of orthopedic implants.

  • Supervisors: S. Berthe (ICube), M. Ehlinger (CHRU, ICube), M. Boillat (ICube)
  • Master's student: Nasma Drissi

Developing skull-adaptive deep learning models for real-time acoustic wave propagation simulation for transcranial focused ultrasound

Focused ultrasound (FUS) can temporarily, safely and non-invasively open the blood-brain barrier (BBB) to deliver drugs that would not otherwise penetrate brain tissue. These procedures require planning stages based on lengthy multiphysics simulations. This project aims to explore the synergy between physical models and deep learning approaches to calculate acoustic pressure maps in the brain in real time, to help physicians plan the operation quickly, accurately and safely.

  • Supervisors: V. Srivastav (ICube), P. Cabras (IGT, ICube), N. Padoy (ICube, IHU Strasbourg)
  • Master's student: Berkay Oztas

Distributed impedance control for surgical continuum robots

This project focuses on the control of continuum robots for minimally invasive surgical applications. Controlling such long, flexible robots, interacting with the patient anatomy at any point along their length is a challenge, which we will tackle using a combination of impedance control algorithms and a recently developed generalized compliance model. Validation will be performed on a concentric tube robot prototype available at ICube.

  • Supervisors: B. Rosa (ICube), H. Omran (ICube)
  • Master's student: Mattia Reina

Innovative Electromagnetic Tracking System for Assisted-Surgery Navigation

Electromagnetic tracking in surgery enables the real-time localization of medical tools inside the human body without requiring a direct line of sight. This technology is pivotal in minimally invasive procedures by improving accuracy and safety. The goal of this project is to explore the potential of emerging magnetic sensor technologies to extend the operational tracking range and enhance robustness, while also focusing on the miniaturization of the sensing element embedded within the surgical instrument to facilitate integration and reduce invasiveness.

  • Supervisors: M. Madec (ICube)
  • Master's student: Ali Salman

DELIMAD - DEep Learning for IMaging biomarkers in Alzheimer’s Disease and Dementia with Lewy Bodies using anatomical and diffusion MRI

 

This project focuses on enhancing the understanding of neurodegenerative diseases, such as
Alzheimer’s and Dementia with Lewy bodies, through the analysis of structural brain imaging data. By
leveraging quantitative metrics derived from standard MRI processing (brain volumes and structural
connectivity), the student will develop deep learning models aimed at identifying specific early
biomarkers, with the potential to significantly improve diagnostic accuracy and patient care.

  • Supervisors: M. Mondino (ICube), J. Pontabry (ICube)
  • Master's student: Nathan Schaff

Towards real-time control of ultrasound-induced cavitation for non-invasive drug delivery

Focused ultrasound (FUS) are promising, non-invasive image-guided therapies that can be used for localized drug delivery thanks to ultrasound-induced cavitation. The ICube laboratory has developed a new MRI-guided cavitation imaging method for monitoring these therapies. However, this method is currently postoperative with offline evaluation. The objective of this project is to render it real-time in order to control the FUS generator and subsequently to control the induced cavitation effects. 

  • E. Breton (ICube), L. Cuvillon (ICube), J. Vappou (ICube)
  • Master's student: Jacopo Tanzini

Human balance disorders after a head trauma: finite element approach to simulate injury biomechanics in the inner ear

This research proposal aims to establish why vertigo and instabilities are usually observed and diagnosed after a head trauma that may occur in traffic accidents, sport activities impacts or domestic life falls. In particular, this work uses various existing and validated finite element models of the vestibule of the human inner ear to identify what happens to the cupula and the surrounding tissues during an extended range of head accelerations/decelerations.

  • Supervisors: D. Baumgartner (ICube), A. Charpiot (HUS, ICube)
  • Master's student: Rosemarie Valcourt

Inference of Attentional Mechanisms in Cognitive Tasks

This project aims to understand attentional mechanisms in cognitive tasks, focusing on the processing of music, speech, and rest, by confronting advanced computational and inference tools against invasive neuroimaging recordings Stéréo Electroencéphalogramme (SEEG recorded in epileptic patients). We will use simulation-based inference and generative modeling to explore neural dynamics underlying attention, leveraging tools like Recurrent Switching Linear Dynamical Systems (rsLDS), an unsupervised machine learning tool that helps us automatically identify distinct brain states from brain activity data, leveraging The Virtual Brain (TVB) and vbjax, as software tools for simulating brain activity developed at INS. We will explore integrating self-attention from transformer models into Neural Field Models (NFMs) to simulate cognitive processes. We also aim to develop The Virtual Brain (TVB) Agent, an AI assistant utilizing Large Language Models (LLMs) to automate brain simulation workflows for TVB. This interdisciplinary approach seeks to advance both our understanding of brain function and the efficiency of computational neuroscience research.

  • Supervisors: M. Hashemi (Institut de neurosciences des systèmes), M. Woodman (Institut de neurosciences des systèmes)
  • Master's student: Sadel Muwahed